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Su-11274 exhibits a selective inhibition pattern toward different receptor mutated variants
PubMed PMID: 16515549
InChi: InChI=1S/C18H19F3N2O4S2
PubMed PMID: 10762053
MI-2 was nontoxic to mice
UF010 - HDAC Inhibitor. CAS# 537672-41-6 Catalog No.:M60278-2S Su-11274 exhibits a selective inhibitionUF 010, CAS No. 537672 41 6, is a Class I HDAC inhibitor (IC50 values are 0. 06, 0. 1, 0. 5 and 1. 5 M for HDACs 3, 2, 1 and 8, respectively). UF010 inhibits cancer cell proliferation via class I HDAC inhibition. This causes global changes in protein acetylation and gene expression, resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways. The isotype selectivity coupled with interesting biological
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